Umbrella Project II
Larvicides and Antimicrobials from Abundant Natural Sources
In this research line, SINTMOL Lab researchers focus on the development of compounds with larvicidal activity against Aedes aegypti, the mosquito vector of the dengue virus, as well as on the exploration of abundant and renewable natural sources for the discovery of new antimicrobial agents.
Selected Publications
- Copini, S. ; MICHELETTI, A. C. ; De Souza, A. M. ; Gomes, R. S. ; De Lima, D. P. ; BEATRIZ, A. Synthesis and Antioxidant and Antimicrobial Properties of β-Hydroxy Sulfides, Sulfoxides, and Sulfones Derived from Cardanol and Glycerol Derivatives. J. Braz. Chem. Soc. 2020, 31, 2569-2582.
- Juliana Miron Vani, Maria Tereza Ferreira Duenhas Monreal, Sarah Alves Auharek, Andréa Luiza Cunha-Laura, Eduardo José de Arruda, Alessandra Ramos Lima, Cicera Maria da Silva, Andréia Conceição Milan Brochado Antoniolli-Silva, Dênis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira. The mixture of cashew nut shell liquid and castor oil results in an efficient larvicide against Aedes aegypti that does not alter embryo-fetal development, reproductive performance or DNA integrity. Plos One 2018, 1-21.
- de Oliveira, P. D. et al. Ozonolysis of neem oil: Preparation and characterization of potent antibacterial agents against multidrug resistant bacterial strains. RSC Advances 2017, 7, 34356-34365.
- Vani, J.M.; Auharek, S. A. et al. Tensoativo do Líquido da Casca da Castanha do Caju: eficiente larvicida natural, contra o Aedes aegypti, de uso seguro. PECIBES 2015, supl. 1, 24.
- Kogawa, N. R. A.; De Arruda, E. J.; Micheletti, A. C.; Matos, M. F. C.; De Oliveira, L. C. S.; De Lima, D. P.; Carvalho, N. C. P.; Oliveira, P. D.; Cunha, M. C.; Ojeda, M.; Beatriz, A. Synthesis, characterization, thermal behavior and biological activity of ozonides from vegetable oils. RSC Advances: an international journal to further the chemical sciences, 2015, 5, 65427 – 65436.
- Almeida, N. R.; Beatriz, A.; Micheletti, A. C.; de Arruda, E. J. Ozonized vegetable oils and therapeutic properties: A review. Orbital: Electron. J. Chem. 2012, 4, 313.
- Beatriz, A. et al. Processo de Produção e Uso de Misturas de Surfactantes Iônicos do Líquido da Casca da Castanha do Caju e do Óleo de Mamona como Larvicida. Patent no. BR 10 2015 0072333.