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The SINTMOL Lab (or just LP4) is designed to address the specialized training needs of undergraduate and graduate students, providing a cutting-edge facility for researching the synthesis of organic compounds with unique properties.

Current major investigations at SINTMOL Lab focus on:

Organic Chemistry and Medicinal Chemistry

• Synthesis of natural and bioactive compounds
• Structural transformations to modify or enhance the biological activities of natural products
• Development of new products from abundant renewable raw materials, such as glycerol, cashew nut shell liquid (CNSL), and vegetable oils (aligned with Bioeconomy and Green Chemistry principles)
• Synthesis of active pharmaceutical ingredients (APIs) using batch and continuous flow chemistry
• C(sp2)-H bond activation and functionalization
• Chalcogenation of heterocyclic compounds
• Computer-aided drug design (CADD), including molecular docking and molecular dynamics simulations, to predict ligand-target interactions, guide synthetic strategies, and rationalize structure-activity relationships (SAR)

Biotechnology and Chemical Biology

• Discovery of new antimicrobials from fungi through molecular bioprospection
• Application of biotransformations and biocatalysis to create derivatives from natural and synthetic substrates (emphasizing Green Chemistry)
• Production of antibiotics via fermentation
• Molecular Biology studies
• Metabolomics (LC-MS/MS and NMR-based) for comprehensive profiling, annotation, and dereplication of natural products from microorganisms
• Integration of metabolomics with bioprospecting and synthetic approaches to identify bioactive metabolites and prioritize targets for isolation and chemical modification

Translational and Integrative Approaches

• Integration of synthetic chemistry, metabolomics, and molecular modeling for the discovery and optimization of bioactive compounds
• Data-driven strategies combining omics and in silico methods to accelerate drug discovery pipelines (antimicrobial and anticancer agents)

Support

Location:

Institute of Chemistry of the Federal University of Mato Grosso do Sul

Av. Senador Filinto Müller, 1555 – Vila Ipiranga, CEP: 79074-460 – Campo Grande – MS, Brazil.

Phone: +55 67 3345 3578

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