Organic Synthesis

Synthetic Organic Chemistry is a cornerstone for the production of pharmaceuticals, polymers, fertilizers, pesticides, cosmetics, clothing and technological materials. The mechanism that directs and improves our ability to create such molecules through synthesis is the total synthesis. It can be said that organic synthesis has 3 key pillars: technique, logic and methods. In syntheses today more environmental issues are considered in planning than in the syntheses developed in the past. The environmental impact caused by each step and reagent used in synthesis has been increasingly discussed and put on the agenda for the development of new synthetic routes.

Organic Synthesis and Medicinal Chemsitry: The discovery and development of new natural or synthetic organic compounds for biomedical use is a critical component of research in medicinal chemistry. Therefore, organic synthesis plays a central role in any endeavor to develop new molecules for biological and/or technological applications. For example, the process for producing a drug, from discovering a molecule with a promising structure for a given biological target to its marketing, goes through various process that aim to ensure its effectiveness, and also seek better ways to produce the thing consumed. Thus, it is a constant concern of synthetic organic chemistry to search for profitable routes that minimize the loss of reagents and reduce the production of chemical residues.

In this context, the SINTMOL Laboratory is among the pioneering laboratories in the State of Mato Grosso do Sul that focuses on Organic Synthesis as a central area of its research activity. The SINTMOL laboratory currently hosts environmentally focused projects that incorporate green chemistry principles and sustainability goals into the research objectives of its projects.

Organic Synthetic Methodology

Our main aim is to develop new organic synthetic methodology for the preparation of bioactive compounds, in an efficient, reliable and simple manner.

Research areas:

  • Organic reactions enabled by aqueous micellar catalysis
  • Multicomponent reactions (MCRs)
  • C(sp2)-H bond activation/functionalization
  • Chalcogenation of heterocyclic compounds
  • Photochemical reactions

Green Chemistry

Research areas:

  • Use of biocatalysis to generate derivatives from natural and synthetic substrates
  • Synthesis of new polymers, surfactants, liquid crystals, biodiesel, and further products from abundant renewable raw materials—glycerol, cashew nut shell liquid (CNSL), vegetable oils, etc. 
  • Cardanol and Glycerol Exploitation
  • Larvicides and antimicrobials from abundant natural sources
  • Development of environmentally benign organic synthetic protocols, organochalcogen (S, Se, Te) chemistry, C(sp2)-H bond activation/functionalization, chalcogenation of heterocyclic compounds, catalysis, photochemical reactions, synthesis of small molecules with pharmacological applications.