Production of antibiotics

Antibiotic production by microorganisms is one of their more interesting features, particularly from a medical and commercial point of view. Penicillins and cephalosporins belong to the class of drugs known as β-lactams. Naturally produced penicillins by Penicillium chrysogenum are classified as 1st generation. The 2nd, 3rd and 4th generations are all semi-synthetic obtained from chemical synthesis starting from 6-APA. The cephalosporins in clinical use are semi-synthetic derivatives of 7-ACA, obtained from cephalosporin C, produced by Acremonium chrysogenum. Semi-synthetic penicillins and cephalosporins continue to interest many research groups to discover new antibiotics that may tackle super bacteria. 6-APA and 7-ACA are essential starting materials used in studies on the synthesis of the β-lactams drugs. We are interested in producing 6-APA and 7-ACA by biotechnological processes.