Multidisciplinary Approaches to Dengue and Other Neglected Diseases

Our group has long been active in the development of compounds to eliminate larvae of Aedes aegypti, the mosquito vector of the dengue virus. The group’s interests extend to the synthesis of organic compounds for use in combating neglected diseases (including leishmaniasis, tuberculosis, and Chagas disease), as well as to the design of educational materials (scientific dissemination) for the prevention of these diseases.

Researchers

• Dr. Adilson Beatriz  – UFMS
• Dr. Ana Camila Micheletti – UFMS
• Dr. Antonio Pancracio de Souza – UFMS
• Dr. Dênis Pires de Lima – UFMS
• Dr. Eduardo José de Arruda – UFGD
• Dr. Marilyn Aparecida Errobidarte de Matos – IFMS
• Dr. Roberto da Silva Gomes – UFGD

Lines of research

• Biology and control of insect vectors
• Synthesis of new insecticides and strategies for insect vector management
• Organic synthesis and medicinal chemistry
• Information technology and communication in environmental education and health

Further output

Articles

• Juliana Miron Vani, Maria Tereza Ferreira Duenhas Monreal, Sarah Alves Auharek, Andréa Luiza Cunha-Laura, Eduardo José de Arruda, Alessandra Ramos Lima, Cicera Maria da Silva, Andréia Conceição Milan Brochado Antoniolli-Silva, Dênis Pires de Lima, Adilson Beatriz, Rodrigo Juliano Oliveira. The mixture of cashew nut shell liquid and castor oil results in an efficient larvicide against Aedes aegypti that does not alter embryo-fetal development, reproductive performance or DNA integrity. Plos One 2018, 1-21.
• Bhaskar R. Manda; Avvari N. Prasad; Narendar R. Thatikonda; Valdemar Lacerda Jr.; Layla R. Barbosa; Heloa Santos; Wanderson Romão; Fernando R. Pavan; Camila M. Ribeiro; Edson A. dos Santos; Maria R. Marques; Dênis P. de Lima; Ana C. Micheletti; Adilson Beatriz. Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol‑Based β-Amino Alcohol Derivatives. J. Braz. Chem. Soc. 2017.
• Paiva, D. R.; De Lima, D. P.; Avvari, N. P. ; Arruda, E. J.; Cabrini, I.; Marques, M. R.; Santos, E. A.; Biaggio, F. C.; Sangi, D. P.; Beatriz, A. A potent larvicidal agent against Aedes aegypti mosquito from cardanol. Anais da Academia Brasileira de Ciências.  In Press, 2017.
• NAUJORKS, ALINE ALVES DOS SANTOS ; DA SILVA, ADRIANO OLÍMPIO ; LOPES, ROSANGELA DA SILVA ; DE ALBUQUERQUE, SÉRGIO ; BEATRIZ, ADILSON ; MARQUES, Maria Rita ; de Lima, Dênis Pires. Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities. Organic & Biomolecular Chemistry, v. 13, p. 428-437, 2014.
• MICHELETTI, A. C. ; HONDA, N. K. ; Pavan, F.R. ; Leite, C. Q. F. ; MATOS, Maria de Fátima Cepa ; PERDOMO, R. T. ; BOGO, D. ; Alcântara, G. B. ; BEATRIZ, A. Increment of Antimycobaterial Activity on Lichexanthone Derivatives. Medicinal Chemistry (Hilversum), v. 9, p. 904-910, 2013.
• OLÍMPIO DA SILVA, ADRIANO ; DA SILVA LOPES, ROSANGELA ; VIEIRA DE LIMA, RICARDO ; SANTOS SUNIGA TOZATTI, CAMILA ; MARQUES, Maria Rita ; DE ALBUQUERQUE, SÉRGIO ; BEATRIZ, A. ; De Lima, D. P. ; PIRES DE LIMA, DÊNIS . Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones. European Journal of Medicinal Chemistry, v. 60, p. 51-56, 2013.
• Micheletti, Ana Camila ; BEATRIZ, A. Progressos Recentes na Pesquisa de Compostos Orgânicos com Potencial Atividade Antileishmanicida. Revista Virtual de Química, v. 4, p. 268-286, 2012.
• De Almeida, N. R. ; MICHELETTI, A. C. ; BEATRIZ, A. ; De Arruda, E. J.  Ozonated vegetable oils and therapeutic properties: A Review. Orbital: the Electronic Journal of Chemistry, v. 4, p. 313-326, 2012.
• Honda, N.K. ; Pavan, F.R. ; Coelho, R.G. ; de Andrade Leite, S.R. ; Micheletti, A.C. ; Lopes, T.I.B. ; Misutsu, M.Y. ; BEATRIZ, A. ; Brum, R.L. ; Leite, C.Q.F. . Antimycobacterial activity of lichen substances. Phytomedicine (Stuttgart), v. 17, p. 328-332, 2009.

Books

• Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

Editors: Adilson Beatriz and Dênis Pires de Lima

DOI: 10.2174/97816080590271140101

eISBN: 978-1-60805-902-7, 2014

ISBN: 978-1-60805-903-4

Master’s theses and doctoral dissertations

• Marilyn A. Errobidarte de Matos. Panorama do controle da dengue pelas ações dos Agentes de Combate às Endemias no município de Campo Grande – MS. Doutorado em Meio Ambiente e Desenvolvimento Regional. Universidade para o Desenvolvimento do Estado e da Região do Pantanal, UNIDERP,  2017.

Softwares

Videos

Articles and interviews for a broader readership (newspapers and magazines)

• Governo de MS estuda combater Aedes com mosquito transgênico. Prof. Antônio Pacrácio de Souza – G1 – 22/01/2016
• Chemistry: A key science to fight neglected diseases. Prof. Adilson Beatriz e Dênis P. de Lima – Orbital: the Electronic Journal of Chemistry, Internet, p. i – iii, 30 jan. 2010.
• Mosquito da Dengue pode sobreviver se alimentando apenas de plantas – Prof. Antônio Pacrácio de Souza – Correio do Estado – 06/07/2011