Design, Synthesis and in vitro Antimicrobial Activity Evaluation of Novel Hybrids of Lichexantone-THC Derivatives
Ana Camila Micheletti, Neli Kika Honda, Nadia Cristina Pereira Carvalho, Dênis Pires de Lima, Adilson Beatriz
Two novel hybrid lichexantone-THC (benzopirane group) derivatives as potential antimicrobial agents were designed and prepared from norlichexanthone and (S)-cis-verbenol in two steps. The newly synthesized compounds were characterized by 1H-NMR, 13C-NMR and MS. In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium) and Gram- negative (Escherichia coli, Enterobacter cloacea, Klebisiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) bacterial strains. The bioassay results indicate that the compounds namely 5 and 6 proved active against Gram-positive strains (standard and clinical) in comparison with reference drugs.
Orbital: Electron. J. Chem. 2015, 7, 301-307.