Production of antibiotics

Antibiotic production by microorganisms is one of their more interesting features, particularly from a medical and commercial point of view. Penicillins and cephalosporins belong to the class of drugs known as β-lactams. Naturally produced penicillins by Penicillium chrysogenum are classified as 1^st generation. The 2^nd, 3^rd and 4^th generations are all semi-synthetic obtained from chemical synthesis starting from 6-APA. The cephalosporins in clinical use are semi-synthetic derivatives of 7-ACA, obtained from cephalosporin C, produced by Acremonium chrysogenum. Semi-synthetic penicillins and cephalosporins continue to interest many research groups to discover new antibiotics that may tackle super bacteria. 6-APA and 7-ACA are essential starting materials used in studies on the synthesis of the β-lactams drugs. We are interested in producing 6-APA and 7-ACA by biotechnological processes.

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The SINTMOL Lab is a part of the CIBSINT

The CIBSint (Center for Research and Innovation in Bioprospecting and Synthesis of Products for Human and Animal Health) is an important initiative for the research, development, and innovation of products useful for health and agriculture, with the potential to generate positive impact on society and the country's economy.

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