{"id":2336,"date":"2018-02-12T10:58:52","date_gmt":"2018-02-12T14:58:52","guid":{"rendered":"https:\/\/sintmol.ufms.br\/?p=2336"},"modified":"2018-02-12T21:29:59","modified_gmt":"2018-02-13T01:29:59","slug":"accepted-paper-chemical-biology-letters-design-synthesis-structure-activity-relationship-novel-phenolic-based-pyrimidine-hybrids-cashew-nut-shell-liquid-cnsl-components-potential","status":"publish","type":"post","link":"https:\/\/sintmol.ufms.br\/en\/accepted-paper-chemical-biology-letters-design-synthesis-structure-activity-relationship-novel-phenolic-based-pyrimidine-hybrids-cashew-nut-shell-liquid-cnsl-components-potential\/","title":{"rendered":"Accepted paper in Chemical Biology Letters: Design, synthesis and Structure-Activity Relationship of novel Phenolic based&#8230;."},"content":{"rendered":"<div id=\"articleTitle\">\n<h3>Design, synthesis and Structure-Activity Relationship of novel Phenolic based Pyrimidine hybrids from Cashew Nut Shell Liquid (CNSL) components as potential antitumor agents<\/h3>\n<\/div>\n<div id=\"authorString\"><em>Thatikonda Narendar Reddy, Adilson Beatriz, Rosangela da Silva Lopes, Maria Rita Marques, Edson dos Anjos dos Santos, Camila Izabela Nantes, Maria de F\u00e1tima Cepa Matos, Renata Trentin Perdomo, Indiara Correia Pereira, Simone Schneider Weber,&nbsp;D\u00eanis Pires de Lima<\/em><\/div>\n<p><a href=\"https:\/\/sintmol.ufms.br\/files\/2018\/02\/cover_article_753_en_US.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft size-medium wp-image-2337\" src=\"https:\/\/sintmol.ufms.br\/files\/2018\/02\/cover_article_753_en_US-300x212.jpg\" alt=\"\" width=\"300\" height=\"212\" srcset=\"https:\/\/sintmol.ufms.br\/files\/2018\/02\/cover_article_753_en_US-300x212.jpg 300w, https:\/\/sintmol.ufms.br\/files\/2018\/02\/cover_article_753_en_US-150x106.jpg 150w, https:\/\/sintmol.ufms.br\/files\/2018\/02\/cover_article_753_en_US-452x320.jpg 452w, https:\/\/sintmol.ufms.br\/files\/2018\/02\/cover_article_753_en_US.jpg 537w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>Abstract: Herein we describe a simple method for the synthesis of Baylis-Hillman adducts and their acetates by utilizing inexpensively available cashew nut shell liquid (CNSL) natural resources. Furthermore, by using a molecular hybridization approach, a series of novel pyrimidine scaffolds (<strong>15a-15t<\/strong>) were synthesized via utilizing Baylis-Hillman acetates derived from cashew nut shell liquid (CNSL). All the newly synthesized compounds were screened for their in vitro antitumor activity. Baylis-Hillman compounds&nbsp;<strong>5b&nbsp;<\/strong>and&nbsp;<strong>5h<\/strong>&nbsp;showed promising anticancer activity against MCF-7. Among pyrimidine derivatives, compounds&nbsp;<strong>15i<\/strong>,&nbsp;<strong>15j<\/strong>&nbsp;and&nbsp;<strong>15l<\/strong>&nbsp;showed promising activity against HEP-G2, whereas compounds&nbsp;<strong>15j<\/strong>,&nbsp;<strong>15k<\/strong>,&nbsp;<strong>15l<\/strong>&nbsp;and&nbsp;<strong>15m<\/strong>&nbsp;showed promising activity against MCF-7. In addition, compound&nbsp;<strong>15m<\/strong>showed significant activity against K562 when compared with the standard. The structure-activity relationship (SAR) analysis suggests that the length of the carbon chain of phenyl ring played an important role in the potency of activity<\/p>\n<p>&nbsp;<\/p>\n<p>Journal: <a href=\"http:\/\/pubs.iscience.in\/journal\/index.php\/cbl\/article\/view\/753\" target=\"_blank\" rel=\"noopener noreferrer\">Chemical Biology Letters ,&nbsp;2018, 5(2), 41-54<\/a><\/p>\n<h3>Related Images:<\/h3>","protected":false},"excerpt":{"rendered":"<p>Design, synthesis and Structure-Activity Relationship of novel Phenolic based Pyrimidine hybrids from Cashew Nut Shell Liquid (CNSL) components as potential antitumor agents Thatikonda Narendar Reddy, Adilson Beatriz, Rosangela da Silva Lopes, Maria Rita Marques, Edson dos Anjos dos Santos, Camila Izabela Nantes, Maria de F\u00e1tima Cepa Matos, Renata Trentin Perdomo, Indiara Correia Pereira, Simone Schneider [&hellip;]<\/p>\n","protected":false},"author":126,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3,4,1],"tags":[],"coauthors":[],"class_list":["post-2336","post","type-post","status-publish","format-standard","hentry","category-fotos-imagens","category-destaques","category-noticias"],"_links":{"self":[{"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/posts\/2336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/users\/126"}],"replies":[{"embeddable":true,"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/comments?post=2336"}],"version-history":[{"count":4,"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/posts\/2336\/revisions"}],"predecessor-version":[{"id":2341,"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/posts\/2336\/revisions\/2341"}],"wp:attachment":[{"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/media?parent=2336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/categories?post=2336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/tags?post=2336"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/sintmol.ufms.br\/en\/wp-json\/wp\/v2\/coauthors?post=2336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}